Pka value of ibuprofen

Ibuprofen

Ibuprofen (Advil or Motrin) is a prescription medication used to treat mild to moderate pain in adults and children aged 12 years and older. It works by relieving muscle pain and reducing fever. This pain medication contains ibuprofen, which belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

You should take this medication exactly as your doctor has told you. Do not take ibuprofen more often than directed. It is important to continue taking this medication even if you feel well. If you are taking ibuprofen for pain relief, your doctor will advise you on the best dose for your particular case. If your pain does not improve or worsens after one week, your doctor may increase your dose of ibuprofen.

How to use this medicine

If you take ibuprofen for pain relief, do not exceed the recommended dose. If you stop taking this medication within a week of completing treatment, your symptoms may worsen. Ask your doctor or pharmacist for more details.

Keep using this medication as directed and do not exceed the recommended dose. If you have any side effects, talk to your doctor.

Do not take any other medications unless they have been discussed with your doctor. Ibuprofen can interact with other medicines you are taking, especially:

  • medicines used to treat migraines
  • anticoagulants used to lower the risk of bleeding in children
  • anti-diarrhea medicines used to treat conditions such as constipation
  • medicines used to help prevent the growth of certain types of bacteria in your body

Before starting treatment with this medication, tell your doctor if you have any health problems, including kidney or liver problems or a history of bleeding disorders. Your doctor may need to adjust your dose or prescribe another medication, so be sure to inform their office of details when taking this medication.

Tell your doctor or pharmacist if you are taking any of the following:

  • corticosteroids such as prednisone or dexamethasone. This medication is also used for the relief of cold and allergy symptoms associated with colds and allergies
  • ibuprofen
  • steroids used to lower the risk of bleeding in children
  • methotrexate
  • medicines used to treat arthritis pain
  • NSAIDs that are taken by mouth.
  • medicines that are taken by mouth such as acetylsalicylic acid (ASA) or ibuprofen.
  • medicines used to treat conditions such as:
  • stomach ache and diarrhea
  • stomach aches and vomiting
  • blood clotting or clotting disorders
  • liver or kidney problems
  • low blood pressure or a history of
  • stomach or abdominal pain, nausea or vomiting.

This medication may decrease the effectiveness of certain medicines. If your doctor has prescribed this medication, you should tell your doctor or pharmacist before you take any new medicines.

Side effects

The most common side effects of this medication are stomach upset, constipation, nausea, dizziness, drowsiness, headache, and upset stomach.

Less common side effects may include:

If you experience severe side effects such as chest pain or easy bruising, or you have difficulty breathing, call your doctor immediately. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may report to your health care provider or a doctor.

Frequently Asked Questions

Is ibuprofen safe to take for pain?

ibuprofen isnot recommended for use in children under 12 years of age.

What should I know before I take ibuprofen?

Read the Patient Information and Information leaflet before taking this medicine.

Can I take ibuprofen if I am pregnant or breastfeeding?

No, you should not take ibuprofen if you are pregnant or breastfeeding.

The Food and Drug Administration (FDA) has issued warnings about a variety of products for which ibuprofen may be linked. These products include:

  • Omeprazole (Prilosec, Zegerid, Zegerid XR)
  • Apo-Prilosec (Pristiq, Propranolix, Solodyn, Solodyn ER, Solodyn XL, Solodyn XL XR)
  • Duloxetine (Cymbalta, Cymbalta XR)
  • Tolvaptan (Paxil, Prevacid, Prevacid XL)
  • Toremifene (Norpramin, Trimox, Trimox XL, Trimox XR)
  • Topiramate (Qvar, Topamax, Topamax XR)
  • Valproic acid (Depakene, Valproate, Depakene XR)
  • Triamterene (Triamterene, Zytiga, Zytiga SR)
  • Tolvaptan (Depakene, Zydena, Depakene XR)

These products may cause a temporary or permanent decrease in blood pressure, dizziness, and lightheadedness. The FDA warns consumers to take precautions before taking any of these products and to report any side effects to their healthcare provider. These products are not intended for use by women.

The FDA said this information is for educational purposes only and may not replace or substitute for professional medical advice.

The FDA has issued two warnings to consumers on the products listed below:

  • Tolvaptan (Depakene, Valproate, Valproate XL, Valproate SR)

The FDA also has issued a warning about a product called "Topiramate" (Qvar, Topamax, Topamax XR). This product may cause a temporary decrease in blood pressure that may be associated with dizziness and lightheadedness.

The FDA has issued a warning to consumers on the products listed below:

  • Triamterene (Triamterene, Zydena, Zydena SR)
This content is for informational purposes only and should not be considered as medical advice. It may not be correct information about other products and their ingredients.

Key takeaways

  • This study was supported by the Ministry of Education and Research (MOPIR) in collaboration with the Swedish Research Council (SERB2) and the Swedish Medical Research Council (MR tsp) and Swedish Cancer Society (SCC-0104 and SCC-0450) and the Swedish Research Foundation (SREF-3112).
  • A study showed that ibuprofen and naproxen are more effective at reducing inflammation than ibuprofen and ibuprofen and naproxen are more effective at reducing inflammation than ibuprofen and naproxen.
  • This study was presented at the European Association of Cancer Research (EAACR) Scientific Sessions 2015 and 2017, which was presented at the annual meeting of the European Association of Cancer Research (EAACR) Cancer Society 2016 and 2016. This was supported by the Swedish Research Council for the support of the scientific excellence.

Methods

The study was carried out by two research teams (H. B. and J. S. S.) on the use of ibuprofen and naproxen in the prevention and treatment of musculoskeletal and joint disorders.

The study was a phase II study, with two parallel-arm trials in which participants were randomly assigned to receive either ibuprofen or naproxen at either a low or medium dose. Participants were included when they were aged 50 years or older, or in the first six months of treatment. All patients were enrolled at the beginning of the study, and all patients were assessed by a health professional if they were unable to stop the treatment, were pregnant or breastfeeding, were on a non-steroidal anti-inflammatory drug (NSAID) or on non-steroidal anti-inflammatory (NSAID only) therapy at the time of the study, and were aged 18 to 65 years old. At the start of the study, participants were advised to stop taking ibuprofen and naproxen. Participants were also told that they would continue to take ibuprofen and naproxen at the same time every day, and they were to take it for the duration of their study, but they did not change their doses over time. If participants stopped taking ibuprofen and naproxen, they were instructed to stop taking the medication. They also received information on the reasons for their stopping and the risks of their discontinuation.

Participants who were taking ibuprofen and naproxen for more than one month at the time of the study were asked to stop taking the medication. They were also asked to report if they had any side effects from ibuprofen and naproxen.

Participants who stopped taking ibuprofen and naproxen were asked to report if they had any side effects from the use of ibuprofen and naproxen, or if they had any side effects from naproxen.

Participants were asked to report if they had any side effects from the use of ibuprofen and naproxen, or if they had any side effects from naproxen.

All participants were asked to report any side effects that lasted more than 10 days. They also were asked to report any adverse events they experienced during the last 6 months, including side effects related to joint pain or fractures, or side effects related to other medications. Any side effects were reported by participants and documented by a health professional.

Results

A total of 9,814 participants (9,943 women, 9,943 men) were enrolled, of which 7,891 (66.7%) were men, and 9,071 (66.2%) were women. Most participants (7,891/9,814) were aged between 18 to 65 years old. One person (0.5%) had a BMI of 30 or more; one person (0.5%) had a BMI of 27 or more; and one person (0.5%) had a BMI of less than 25. The majority of participants (7,891/9,814) were of non-smokers, (9,117/9,814) had had a personal history of musculoskeletal diseases, and (9,115/9,814) had had a personal history of osteoarthritis. A total of 10,906 participants (10,813 women, 9,812 men) completed the screening and completed follow-up assessments.

Indications

Ibuprofen is indicated for the treatment of: Chronic lower back pain, headaches, muscular strains, neuralgia, dental pain, periodontitis, and other lower respiratory tract infections. For the prevention of upper and lower respiratory tract infections, ibuprofen is also indicated for the treatment of chronic periodontitis.

Dosage

Adults and adolescent patients: The dosage of Ibuprofen in adults should be based on the underlying cause of pain and should not exceed 15 mg/kg/day. The dosage of Ibuprofen in pediatric patients should not exceed 5 mg/kg/day. Dosage of Ibuprofen in adult patients varies depending on the indication, the specific pain and the disease being treated. Children and adolescents: Ibuprofen dosage may need to be reduced to less than 5 mg/kg/day. There are no well-controlled clinical trials to indicate the risks and benefits of reducing the dosage of Ibuprofen in children and adolescents in clinical trials. In summary: Ibuprofen is indicated for the treatment of: Pain in adults; Pain in adults; Pain in adults; Children and adolescents: 5 mg/kg/day. Dosage of Ibuprofen in children < 6 yr: Do not use in children < 6 yr: Use with caution. Dosage of Ibuprofen in elderly patients may be decreased by the use of other nonsteroidal anti-inflammatory drugs, particularly: Other nonsteroidal anti-inflammatory drugs: Concomitant use of aspirin and ibuprofen may be associated with increased cardiovascular collapse and potential hypotension, especially in patients at high risk. Concomitant use of aspirin and Ibuprofen may be associated with increased cardiovascular collapse and potential hypotension, especially in patients at high risk. Do not use Ibuprofen in doses exceeding 15 mg/kg/day if you have any of the following conditions: Severe or active peptic ulcer disease; Moderate or active hepatic disease.

Pregnancy-Lactation

In summary: Ibuprofen should not be used during pregnancy or in the first trimester of pregnancy. The safety and efficacy of Ibuprofen in women with a uterus has not been established. In addition, the risks and benefits of using Ibuprofen in women with a uterus are unknown.

Overdosage

Overdose of Ibuprofen may have adverse effects on the central nervous system and the gastrointestinal and nervous systems, including post-treatment pain and inflammation, and may have therapeutic effects. Symptoms of overdose may include seizures, coma, and/or severe impairment of renal function. The symptoms of overdose may include, but are not limited to: Drowsiness; muscle weakness; loss of coordination; agitation; tremors; headache; vomiting; somnolence; seizures. If you notice any of the symptoms listed below that are not caused by the overdose of Ibuprofen listed above, seek medical attention immediately.

Directions

Adults and adolescent patients: Take this medicine in the dose and duration as advised by your doctor. Do not take more than 1 dose within 24 hours.

Adults and Children: 5 mg/kg/day

Children and adolescents: 5 mg/kg/day - In adults: Take 1-3 mg/kg body weight/day every 12 hours as suggested by the doctor.

Warnings

Ibuprofen may cause hepatotoxicity. Avoid the use of Ibuprofen in the elderly. Do not use in the elderly. In case of severe liver function impairment, the use of non-steroidal anti-inflammatory drugs (NSAIDs) and/or in the case of children and hence elderly patients is required.

Ingredients

Concentrate on the first day of using this medicine. Do not use for more than 4 weeks unless directed by the doctor.

Read the package insert before using this medicine. When using this medicine, make sure that the expiry date printed on the pack is correctly labeled. If the name of the medicine is not printed on the box, the name of the brand or generic medicine.

What is Ibuprofen?

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) which works by blocking the production of prostaglandins, which are substances in the body that cause inflammation.

Ibuprofen is available as an oral capsule and tablet in various dosages and as a liquid. The active ingredient is ibuprofen, which is a white to off-white, non-greasy, slightly orange to off-white solution in which the drug is dissolved in water.

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID).

Ibuprofen in use

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) which works by reducing the production of prostaglandins, which are substances in the body that cause inflammation.

Ibuprofen in use:

The drug is available in a wide range of doses. Ibuprofen is a white to off-white solution in which the drug is dissolved in water.

Ibuprofen is a white to off-white, non-greasy, slightly orange to off-white solution in which the drug is dissolved in water.